AM-2201 (1-(5-fluoropentyl)-3-(1-naphthoyl)indole) is a recreational designer drug that acts as a potent but nonselective full agonist for the cannabinoid receptor. It is part of the AM series of cannabinoids discovere by Alexandros Makriyannis at Northeastern University.
AM-2201 is a full agonist at cannabinoid-1 receptors (CB1Rs) (Chimalakonda et al., 2012), producing psychoactive effects similar to the phytocannabinoid Δ9-tetrahydrocannabinol
Türkiye’de ilk yakalandığı 2011 yılına göre ise yaklaşık 17 kat artış gerçekleşmiştir. Avrupa’da 2014 yılında yayınlanan uyuşturucu raporunda 50.000 ele geçirme vakası olmuş ve bu maddelerin %60’ını sentetik kannabinoidler meydana getirmiştir. Acil servislere, psikiyatri kliniklerine ve aile he-kimlerine başvuran sentetik kannabinoid kullanıcı sayısı giderek artmaktadır. Bu derleme ile toplumdaki tüm bireylerin sağlık sistemi ile ilk temas noktasını oluşturan aile hekimlerine sentetik. kannabinoidler hakkında temel bilgi sunarak onların bilinçlendirilmesi, farkındalıklarının arttırılması amaçlanmıştır.
Consistent with our temperature data, Banister et al. (2015b) demonstrate that intraperitoneal injection of AM-2201 causes transient hypothermia in rats fitted with indwelling biotelemetry transmitters. In their study, intraperitoneal administration of 0.3, 1.0. And 3.0 mg/kg AM-2201 decrease temperature 1–1.5°C, with a maximum effect at 1 hour postinjection.
Also, second less pronounced temperature drop occurred between 4 and 5 hours after administration (≤0.5°C). The authors hypothesized that the second phase of AM-2201. Inaddition, Hypothermia might be due to combined effects of the parent compound and its bioactive metabolites (Banister et al., 2015b). In our study. Besides, subcutaneous administration. Particularly, To rats produced a dose-dependent drop in body temperature that reached a maximum at 2 hours postinjection. Without any indication of a secondary delayed decrease.
Moreover, The subcutaneous dose of 1.0 mg/kg AM-2201 induced a hypothermic response that reache 4°C. Which is more robust than the effects observe after an equivalent intraperitoneal dose in rats (Banister et al., 2015b). Furthermore, present findings agree with our previous results in rats where subcutaneous injections of AM-2201 (Schindler et al. 2017) or JWH-018 (Elmore and Baumann. 2018) induce hypothermia that is maximal after 1–2 hours and slowly returns to normal in a monophasic manner.
Analytical standards were purchased from Cayman Chemical (Ann Arbor, MI) and stored at −20°C until use. AM-2201 for administration to rats was provided by the National Institute on Drug Abuse (NIDA). Drug Supply Program (Rockville, MD). LC-MS–grade water, methanol, and formic acid (Optima LC/MS) were obtains from Thermo Fisher Scientific (Waltham, MA).